Altered grey matter cortical and subcortical T1-weighted/T2-weighted ratio in premature-born adults
Microscopic studies in newborns and animal models indicate impaired myelination after premature birth, particularly for cortical myelination; however, it remains unclear whether such myelination impairments last into adulthood and – if so – are relevant for impaired cognitive performance. It has been suggested that the ratio of T1w and T2w MRI signal intensity (T1w/T2w ratio) is a proxy for myelin content. We hypothesized altered grey matter (GM) T1w/T2w ratio in premature-born adults, which is associated with lower cognitive performance after premature birth.
…